A hotel in a dream often reflects a transitional identity -- who you are between one stage of life and the next, when nothing quite feels permanent yet. Losing your room or wandering unfamiliar hallways can mirror the disorientation of that in-between period, before a new sense of home settles in.
If Mercury be afflicted in the sixth house, the native shall die in prison: if Saturn shall be in the twelfth, and Venus in the eighth, he shall end his days by precipitation. - William Lilly (1602.-1681.)